Papillon+Lefevre+Syndrome

=**- Papillon Lefèvre syndrome** (PLS) -=

The PLS is a very rare Autosomal Recessive Genetic Disorder because the patient in lacking in Cathepsin C (aka Dipeptidyl Peptidase I) Mutations in the cathepsin C gene (CTSC), located at human chromosome, are the cause of PLS. The disorder is inherited in an autosomal recessive manner. This means the defective gene responsible for the disorder is located on an [|auto] some (chromosome 11 is an autosome), and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder. The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene, but usually do not experience any signs or symptoms of the disorder.


 * These are the effects of PLS on people that have the disease:**

Papillon Lefèvre is also known as:

 * Palmoplantar Keratoderma with Periodontosis
 * Palmar-plantar Hyperkeratosis and Concomitant Periodontal Destruction
 * Keratoris Palmoplantaris with Periodontopathia
 * Hyperkeratosis Palmoplantaris with Periodontosis


 * By: Collin Lee**